Table 6.
Crude and adjusted associations between KSHV antibody responses and malaria antibody titres among 1227 children
| ORF73 |
K8.1 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk factor | Prevalence of children with anti-ORF73 antibodies | Crude odds ratios (95% CI) | P | Adjusted odds ratio (95% CI) | P* | Prevalence of children with K8.1 antibodies | Crude odds ratios (95% CI) | P | Adjusted odds ratio (95% CI) | P* |
| PfMSP-1 titres | ||||||||||
| Lowest | 6% (18/307) | 1 | 0.05 | 1 | 0.1 | 13% (939/307) | 1 | 0.6 | 1 | 0.9 |
| Middle | 8% (47/614) | 1.33 (0.76–2.33) | 1.28 (0.72–2.27) | 11% (66/614) | 0.83 (0.54–1.26) | 0.82 (0.53–1.25) | ||||
| Highest | 10% (31/306) | 1.81 (1–3.31) | 1.61 (0.87–2.99) | 14% (43/306) | 1.12 (0.71–1.79) | 1 (0.62–1.61) | ||||
| PfAMA-1 titres | ||||||||||
| Lowest | 5% (16/313) | 1 | <0.0001 | 1 | <0.0001 | 12% (36/313) | 1 | 0.05 | 1 | 0.2 |
| Middle | 5% (33/608) | 1.07 (0.58–1.97) | 1.01 (0.54–1.88) | 10% (61/608) | 0.86 (0.55–1.33) | 0.84 (0.54–1.31) | ||||
| Highest | 15% (47/306) | 3.37 (1.86–6.08) | 2.76 (1.50–5.06) | 17% (51/306) | 1.54 (0.97–2.44) | 1.30 (0.81–2.09) | ||||
*
Adjusted odds ratios were adjusted for socio-demographic factors (sex, household socio-economic status and location). PfMSP-1 (Plasmodium falciparum merozoite surface protein-1), PfAMA-1 (Plasmodium falciparum apical membrane antigen-1), CI (confidence interval), PfMSP-1 and PfAMA-1 antibody titres were analysed using separate regression models.Bold values are statistically significant