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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Cancer Immunol Res. 2015 Jan 27;3(4):389–398. doi: 10.1158/2326-6066.CIR-14-0173

Figure 7. A systemic immune response is generated through local tumor manipulation- a proposed schematic.

Figure 7

Dox MPs injected intratumorally upregulate surface calreticulin expression on dying tumor cells, enhancing their phagocytosis by DCs which migrate to draining lymph nodes and present tumor antigen to antigen-specific T cells. Anti-OX40 enhances T-cell activation while anti-CTLA-4 blocks immunosuppression imposed by CTLA-4, thus allowing tumor-specific T cells to proceed unrestrained to distant tumor sites.