Table 3.

Sensitivity analysis when baseline hazard follows Weibull distribution and when the times to efficacy and dropout follow an accelerated failure time model with a log-logistic error. The bolded numbers are target doses.

		Weibull distribution					Duration (months)
Efficacy	Dropout			Scenario 1
increasing	decreasing	77.7 (25.9)	18.2 (21.4)	0.0 (2.4)	0.0 (0.1)	0.0 (0.0)	22.1
increasing	increasing	77.6 (25.8)	19.4 (21.6)	0.1 (2.3)	0.0 (0.2)	0.0 (0.0)	22.1
decreasing	increasing	77.4 (26.3)	20.1 (21.2)	0.1 (2.5)	0.0 (0.2)	0.0 (0.0)	22.3
decreasing	decreasing	78.1 (26.0)	19.2 (21.6)	0.0 (2.4)	0.0 (0.1)	0.0 (0.0)	22.0
				Scenario 2
increasing	decreasing	3.5 (4.9)	81.0 (28.0)	14.6 (16.2)	0.1 (1.6)	0.0 (0.0)	23.2
increasing	increasing	2.6 (4.8)	82.9 (28.2)	13.1 (15.8)	0.0 (1.6)	0.0 (0.0)	23.2
decreasing	increasing	3.2 (4.9)	83.6 (28.0)	12.9 (16.3)	0.0 (1.6)	0.0 (0.1)	23.2
decreasing	decreasing	3.5 (5.0)	82.6 (28.5)	12.9 (15.7)	0.1 (1.5)	0.1 (0.0)	22.7
		Accelerated failure time model
Efficacy	Dropout			Scenario 1
increasing	increasing	75.9 (25.7)	17.3 (20.8)	0.0 (2.2)	0.0 (0.1)	0.1 (0.0)	22.3
decreasing	increasing	76.4 (25.4)	21.4 (22.1)	0.0 (2.4)	0.0 (0.2)	0.0 (0.0)	22.6
hump shaped	increasing	78.1 (26.5)	17.8 (20.4)	0.0 (2.3)	0.0 (0.1)	0.0 (0.0)	22.4
				Scenario 2
increasing	increasing	4.3 (5.3)	80.9 (28.4)	13.0 (15.1)	0.2 (1.6)	0.0 (0.0)	24.1
decreasing	increasing	2.4 (4.6)	85.0 (29.2)	11.8 (15.3)	0.1 (1.6)	0.0 (0.0)	23.4
hump shaped	increasing	2.9 (4.9)	83.6 (27.8)	12.7 (16.3)	0.0 (1.6)	0.0 (0.0)	23.5