Table 4.
Selection percentage and the average number of patients (shown in parentheses) treated at each dose level under the proposed design and EffTox 1 and 2 designs for scenarios 1, 2, and 3, with no dropout. The bolded numbers are target doses.
| Design | Dose level | Duration (months) |
||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| Scenario 1 | ||||||
| (πE, πT) | (0.42, 0.05) | (0.45, 0.45) | (0.46, 0.65) | (0.47, 0.75) | (0.48, 0.85) | |
| Proposed | 80.4 (27.3) | 15.9 (20.1) | 0.1 (2.3) | 0.0 (0.2) | 0.0 (0.0) | 24.3 |
| EffTox1 | 77.3 (26.1) | 20.1 (20.7) | 0.1 (3.0) | 0.0 (0.3) | 0.0 (0.0) | 47.7 |
| EffTox2 | 77.3 (26.1) | 20.1 (20.7) | 0.1 (3.0) | 0.0 (0.3) | 0.0 (0.0) | 47.7 |
| Scenario 2 | ||||||
| (πE, πT) | (0.41, 0.03) | (0.48, 0.13) | (0.56, 0.45) | (0.63, 0.77) | (0.7, 0.89) | |
| Proposed | 3.0 (4.9) | 83.7 (28.4) | 12.8 (16.0) | 0.1 (1.5) | 0.0 (0.0) | 25.8 |
| EffTox1 | 2.1 (4.3) | 87.4 (27.7) | 10.4 (16.5) | 0.0 (2.3) | 0.0 (0.1) | 47.1 |
| EffTox2 | 2.1 (4.3) | 87.4 (27.7) | 10.4 (16.5) | 0.0 (2.3) | 0.0 (0.1) | 47.1 |
| Scenario 3 | ||||||
| (πE, πT) | (0.3, 0.01) | (0.36, 0.05) | (0.43, 0.17) | (0.51, 0.45) | (0.6, 0.77) | |
| Proposed | 1.3 (3.9) | 6.6 (6.6) | 80.5 (26.0) | 10.2 (12.9) | 0.0 (1.3) | 27.3 |
| EffTox1 | 0.6 (3.5) | 4.1 (5.6) | 84.8 (26.0) | 9.8 (13.6) | 0.0 (2.0) | 48.0 |
| EffTox2 | 0.6 (3.5) | 4.1 (5.6) | 84.8 (26.0) | 9.8 (13.6) | 0.0 (2.0) | 48.0 |