Table 5.
Selection percentage and the average number of patients (shown in parentheses) treated at each dose level under the proposed design with dose-toxicity interactions, with dropout rate about 30%. The bolded numbers are target doses.
| Design | Dose level | Duration (months) |
||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| Scenario 1 | ||||||
| (πE, πT) | (0.24, 0.01) | (0.28, 0.04) | (0.32, 0.1) | (0.43, 0.23) | (0.57, 0.47) | |
| Proposed | 1.3 (3.8) | 8.4 (6.3) | 18.4 (10.3) | 61.8 (21.1) | 9.2 (9.2) | 27.0 |
| Scenario 2 | ||||||
| (πE, πT) | (0.13, 0.02) | (0.32, 0.04) | (0.59, 0.08) | (0.33, 0.13) | (0.15, 0.21) | |
| Proposed | 0.6 (3.6) | 17.3 (9.7) | 66.4 (21.4) | 12.2 (9.9) | 1.7 (5.9) | 26.1 |