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. Author manuscript; available in PMC: 2016 Apr 15.
Published in final edited form as: J Immunol. 2015 Mar 13;194(8):3551–3555. doi: 10.4049/jimmunol.1402262

Figure 1. Loss of PD-1 increases insulin-specific CD4 T cells in NOD mice.

Figure 1

(A) Insulin-specific (insB10-23r3:I-Ag7-tetramer+) CD4 T cells in the pancLN, pancreas, SPL and non-draining LN of pre-diabetic WT (n=21) and PD-1−/− NOD mice (n=8), between 4-7 weeks old, and new onset diabetic NOD.PD-1−/− mice (n=8). (B) Insulitis scores from non-diabetic or diabetic (DB) NOD and NOD.PD-1−/− mice. Data represent >100 islets from each group. Data are compiled from at least 4 experiments.