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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Integr Biol (Camb). 2015 Apr 7;7(4):435–446. doi: 10.1039/c4ib00281d

Fig. 8. Tracking microenvironment modulated osteogenic differentiation using SC-35.

Fig. 8

Cell-material interactions induce osteogenic differentiation by modulating actin dynamics and signaling cascades mediated by RhoA, Fak, and Wnt/β-catenin signaling. These signaling cascades direct changes in the transcriptional machinery that regulate the gene expression and cell phenotype. Our study indicates that SC-35 organizational dynamics are sensitive to these changes and can be used to track osteogenic lineage commitment at early time-points in response to cell-material interactions.