Table 3.
Significant abnormalities of proteins involved in mitochondrial function
| ABCB71 | ATP-binding cassette, sub-family B (MDR/TAP), member 7 |
| ABCD31 | ATP-binding cassette, sub-family D (ALD), member 3 |
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 |
| ABHD112 | abhydrolase domain containing 11 |
| ACACA1 | acetyl-coenzyme A carboxylase alpha |
| ACAD91 | acyl-Coenzyme A dehydrogenase family, member 9 |
| ACLY1 | ATP citrate lyase |
| ACO2 | aconitase 2, mitochondrial |
| ACSL11 | acyl-CoA synthetase long-chain family member 1 |
| ADSL | adenylosuccinate lyase |
| AGPS1 | alkylglycerone phosphate synthase |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 |
| ARMC10 | armadillo repeat containing 10 |
| ASL | argininosuccinate lyase |
| ATAD11 | ATPase family, AAA domain containing 1 |
| ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| ATP5B1,2 | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
| ATP5C12 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
| ATP5D2 | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit |
| ATP5H2 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d |
| ATP5I2 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E |
| ATP6V1E12 | ATPase, H+ transporting, lysosomal V1 subunit E1 |
| ATPIF12 | ATPase inhibitory factor 1; similar to ATPase inhibitor, mitochondrial precursor |
| BAX | Bcl2-associated X protein |
| BCAT2 | branched chain aminotransferase 2, mitochondrial |
| BOLA12 | bolA homolog 1 (E. coli) |
| C1QBP2 | complement component 1, q subcomponent binding protein |
| CCT71 | chaperonin containing Tcp1, subunit 7 (eta) |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 |
| CHCHD32 | coiled-coil-helix-coiled-coil-helix domain containing 3 |
| CLIC4 | chloride intracellular channel 4 (mitochondrial) |
| CLPB1 | ClpB caseinolytic peptidase B homolog (E. coli) |
| CLTC | clathrin, heavy chain (Hc) |
| CLU2 | clusterin |
| COQ92 | coenzyme Q9 homolog (S. cerevisiae) |
| COX2 | COXII |
| COX4I2 | cytochrome c oxidase subunit IV isoform 2 |
| COX5A | cytochrome c oxidase, subunit Va |
| COX5B2 | cytochrome c oxidase subunit Vb |
| CPT1A | carnitine palmitoyltransferase 1a, liver |
| CS | citrate synthase; similar to citrate synthase |
| CTPS21 | CTP synthase II |
| CYB5A | cytochrome b5 type A (microsomal) |
| CYB5R1 | cytochrome b5 reductase 1 |
| CYB5R31 | cytochrome b5 reductase 3 |
| DBI2 | diazepam binding inhibitor (GABA receptor modulator) |
| DIABLO2 | diablo homolog (Drosophila) |
| DNM1L1 | dynamin 1-like |
| DRG21 | developmentally regulated GTP binding protein 2 |
| ETFDH | electron-transferring-flavoprotein dehydrogenase |
| FDPS | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) |
| FKBP8 | FK506 binding protein 8, 38kDa |
| FXN2 | frataxin |
| GARS1 | glycyl-tRNA synthetase |
| GCSH2 | glycine cleavage system protein H (aminomethyl carrier) |
| GM2A2 | GM2 ganglioside activator |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) |
| GPD2 | glycerol-3-phosphate dehydrogenase 2, mitochondrial |
| GRPEL11,2 | GrpE-like 1, mitochondrial |
| HADH2 | hydroxyacyl-Coenzyme A dehydrogenase |
| HADHA | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit |
| HAGH2 | hydroxyacyl glutathione hydrolase |
| HINT22 | histidine triad nucleotide binding protein 2 |
| HK11 | hexokinase 1 |
| HK21 | hexokinase 2 |
| HSP90AB11 | heat shock protein 90kDa alpha (cytosolic), class B member 1 |
| HSPD11,2 | 60 kDa heat shock protein 1 (chaperonin) |
| HSPE11,2 | heat shock protein 1 (chaperonin 10) |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial |
| IDE1 | insulin degrading enzyme |
| ISCU2 | iron-sulfur cluster scaffold homolog (E. coli) |
| KRT5 | keratin 5 |
| LDHA | lactate dehydrogenase A |
| LETM1 | leucine zipper-EF-hand containing transmembrane protein 1 |
| LOC606294 | hypothetical protein LOC606294 |
| LOC6888692 | cytochrome c oxidase, subunit VIb polypeptide 1 |
| LONP11 | lon peptidase 1, mitochondrial |
| LRPPRC | leucine-rich PPR-motif containing |
| LRRC59 | leucine rich repeat containing 59 |
| MAOA1 | monoamine oxidase A |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic |
| MGEA5 | meningioma expressed antigen 5 (hyaluronidase) |
| MGST1 | microsomal glutathione S-transferase 1 |
| MRPL12 | mitochondrial ribosomal protein L1 |
| MRPL122 | mitochondrial ribosomal protein L12 |
| MRPL232 | mitochondrial ribosomal protein L23 |
| MRPL492 | mitochondrial ribosomal protein L49 |
| MRPS232 | mitochondrial ribosomal protein S23 |
| MRPS362 | mitochondrial ribosomal protein S36 |
| MTCH1 | mitochondrial carrier homolog 1 (C. elegans) |
| MTCH2 | mitochondrial carrier homolog 2 (C. elegans) |
| MTHFD11 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| MTHFD1L1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| NARS1 | asparaginyl-tRNA synthetase |
| NDUFA22 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 |
| NDUFAF42 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2 |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7 |
| NDUFS82 | NADH dehydrogenase (ubiquinone) Fe-S protein 8 |
| NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 |
| NLN | neurolysin (metallopeptidase M3 family) |
| NME31 | non-metastatic cells 3, protein expressed in |
| NNT | nicotinamide nucleotide transhydrogenase |
| NRD1 | nardilysin 1 (N-arginine dibasic convertase) |
| OAT | ornithine aminotransferase (gyrate atrophy) |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
| OPA11 | optic atrophy 1 homolog (human) |
| PARK72 | Parkinson disease (autosomal recessive, early onset) 7; similar to DJ-1 |
| PC1 | pyruvate carboxylase |
| PCK21 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PDE12 | phosphodiesterase 12 |
| PEBP11,2 | phosphatidylethanolamine binding protein 1 |
| PHB2 | prohibitin |
| PHB22 | prohibitin 2 |
| PICK1 | protein interacting with PRKCA 1 |
| POR1 | P450 (cytochrome) oxidoreductase |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isoform |
| PRDX62 | peroxiredoxin 6 |
| PRKACA1 | protein kinase, cAMP-dependent, catalytic, alpha |
| PRKCD1 | protein kinase C, delta |
| PSAP2 | prosaposin |
| PTCD3 | Pentatricopeptide repeat domain 3 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 |
| QARS1 | glutaminyl-tRNA synthetase |
| QDPR2 | quinoid dihydropteridine reductase |
| RAB11B1 | RAB11B, member RAS oncogene family |
| RAB351 | RAB35, member RAS oncogene family |
| RAB3D1 | RAB3D, member RAS oncogene family |
| RARS1 | arginyl-tRNA synthetase |
| RGD13069172 | similar to RIKEN cDNA 2900010M23; hypothetical protein LOC687308 |
| RGD1309676 | similar to RIKEN cDNA 5730469M10 |
| RGD1309922 | similar to 2610301G19Rik protein |
| RHOA1 | ras homolog gene family, member A; ras homolog gene family, member C |
| RPL10A | ribosomal protein L10A; similar to ribosomal protein L10a |
| RPS15A | ribosomal protein S15a |
| SARS1 | seryl-tRNA synthetase |
| SDHA1 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
| SFXN1 | sideroflexin 1 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) |
| SLC16A1 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 |
| SLC25A20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
| SNCB2 | synuclein, beta |
| SND1 | staphylococcal nuclease and tudor domain containing 1 |
| SOD12 | superoxide dismutase 1, soluble |
| STOML22 | stomatin (Epb7.2)-like 2 |
| STXBP1 | syntaxin binding protein 1 |
| SUCLA21 | succinate-CoA ligase, ADP-forming, beta subunit |
| SURF4 | surfeit 1; surfeit 4 |
| SYNJ2BP | synaptojanin 2 binding protein |
| TBC1D15 | TBC1 domain family, member 15 |
| TFAM2 | transcription factor A, mitochondrial |
| TFRC | transferrin receptor |
| TH | tyrosine hydroxylase |
| TIMM92 | translocase of inner mitochondrial membrane 9 homolog (yeast) |
| TOMM70A | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) |
| TST | thiosulfate sulfurtransferase, mitochondrial |
| TXN22 | thioredoxin 2 |
| UQCRFS12 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
| VARS1 | valyl-tRNA synthetase 2, mitochondrial (putative); valyl-tRNA synthetase |
| VDAC12 | voltage-dependent anion channel 1 |
| VDAC3 | voltage-dependent anion channel 3 |
1
Proteins that also bind purines.
2
Proteins that were significantly increased; all of the rest were decreased.