Table 4.
Significant decreases involved in proteins for neural transmission in HGprt- PC6-3 cells
| Amine biosynthesis | |
| ASL1 | argininosuccinate lyase |
| ASNS | asparagine synthetase |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) |
| MRI1 | methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) |
| MTHFD11 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| PHGDH | 3-phosphoglycerate dehydrogenase |
| PSAT1 | phosphoserine aminotransferase 1 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) |
| TH | tyrosine hydroxylase |
| Amine binding | |
| AARS1 | alanyl-tRNA synthetase |
| FASN | fatty acid synthase |
| GCLC1 | glutamate-cysteine ligase, catalytic subunit |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) |
| KARS1 | lysyl-tRNA synthetase |
| MAOA1 | monoamine oxidase A |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated gene 4 |
| RARS1 | arginyl-tRNA synthetase |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| TH | tyrosine hydroxylase |
| Neurotransmitter transport | |
| NSF1 | N-ethylmaleimide-sensitive factor |
| RAB141 | RAB14, member RAS oncogene family |
| RAB3C1 | RAB3C, member RAS oncogene family |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| STX1A | syntaxin 1A (brain) |
| STX1B | syntaxin 1B |
| STX7 | syntaxin 7 |
| SV2A | synaptic vesicle glycoprotein 2a |
| SYT1 | synaptotagmin I |
| VAMP2 | vesicle-associated membrane protein 2 |
| Neurotransmitter regulation | |
| MAOA1 | monoamine oxidase A |
| NSF1 | N-ethylmaleimide-sensitive factor |
| RAB141 | RAB14, member RAS oncogene family |
| RAB3C1 | RAB3C, member RAS oncogene family |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| STX1A | syntaxin 1A (brain) |
| STX7 | syntaxin 7 |
| SYT1 | synaptotagmin I |
| TH | tyrosine hydroxylase |
| VAMP2 | vesicle-associated membrane protein 2 |
| Neurotransmitter secretion/release | |
| NSF1 | N-ethylmaleimide-sensitive factor |
| RAB141 | RAB14, member RAS oncogene family |
| RAB3C1 | RAB3C, member RAS oncogene family |
| STX1A | syntaxin 1A (brain) |
| STX7 | syntaxin 7 |
| SYT1 | synaptotagmin I |
| VAMP2 | vesicle-associated membrane protein 2 |
| CADPS | calcium-dependent secretion activator 1; required for Ca++-dependent exocytosis of synaptic vesicles |
| SCAMP3 | secretory carrier-associated membrane protein 3 |
1
Proteins that also bind purines.