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. Author manuscript; available in PMC: 2015 Jul 4.
Published in final edited form as: Neurosignals. 2014 Oct 8;22(2):65–78. doi: 10.1159/000367896

Fig. 3.

Fig. 3

Molecular basis for the higher sensitivity of IK channels to 1-EBIO compared with SK2-a channels. a Amino acid sequences of rat SK2-a and human IK channels at the region of the 1-EBIO binding pocket were aligned. The major SK2-a channel residues that are required for 1-EBIO coordination (Ala477 and Leu480) are highlighted in magenta. The equivalent IK channel residues (Val365 and Met368) are highlighted in blue. b The 1-EBIO binding pocket of SK2-a with the A477V/L480M double mutations. The slightly bulkier residues in the double mutant channel can potentially form better contacts with 1-EBIO. Green spheres: calcium ions.