Table 3. Differentially expressed hepatic genes identified in Xbp1s and Socs3 eQTLs regions that are cis-regulated in BXD mice treated with CCl4.
| eQTL (BXD) | Cis-Regulated Genes (Gene ID) | Gene Location (Mb) | Mean Hepatic mRNA Expression | Max. LOD | Max. LOD Location (Chr:Mb) | nsSNP Variants | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Trait | Location (Mb) | Allele Effecta | B | D | A/J | |||||
| Mgst3: Microsomal glutathione S-transferase 3 (66447) | 169.3 | 9.8 | 6.7 | Chr1: 169.2 | |||||||
| Pex19: Peroxisomal biogenesis factor 19 (19298) | 174.1 | 11.2 | 2.4 | Chr1: 125.0 | |||||||
| 1 | Socs3 | 187.0–187.7 | −0.122 (B) | Dusp23: Dual specificity phosphatase 23 (68440) | 184.6 | 9.6 | 5.7 | Chr1: 174.2 | |||
| Xbp1 | 186.2–186.6 | −0.102 (B) | Apcs: Serum amyloid P-component (20219) | 174.8 | 12.0 | 7.5 | Chr1: 173.0 | ||||
| Darc: Duffy blood group, chemokine receptor (13349) | 175.3 | 8.5 | 5.4 | Chr1: 174.2 | A | G | G | ||||
| Psen2: Presenilin 2 (19165) | 182.2 | 10.8 | 4.3 | Chr1: 182.2 | |||||||
| 11 | Socs3 | 106.5–106.8 | −0.097 (B) | Zfp39: Zinc finger protein 39 (22698) | 58.7 | 8.7 | 10.6 | Chr11: 58.9 | A | G | G |
| 12 | Socs3 | 88.2–89.9 | 0.114 (D) | Amn: Amnionless (93835) | 112.5 | 8.4 | 7.1 | Chr12: 112.4 | T | C | C |
a
Allele effects are estimated change in trait mean (gene expression) by replacement of one allele by the other: negative values indicate that higher expression values are produced by the C57BL/6J (B) allele and positive values by DBA/2J (D) allele.