Table 3. Human orthologs of C. elegans RBPs implicated in PVD dendrite development.
| C. elegans RBP | OrthoDB ID | Human Ortholog | E Value | Brain Expression |
|---|---|---|---|---|
| CGH-1 | EOG7D85W7 | DDX6 | 1.00E-179 | Expressed |
| CPB-3 | EOG751NG9 | CPEB1 | 5.00E-71 | Expressed |
| DCR-1 | EOG78PV82 | DICER1 | 2.00E-167 | Expressed |
| DDX-17 | EOG7HTHGB | DDX17 | 2.00E-163 | Expressed |
| EOG7HTHGB | DDX5 | 5.00E-163 | Expressed | |
| LARP-5 | EOG74J971 | LARP4B | 2.00E-32 | Expressed |
| EOG74J971 | LARP4 | 1.00E-30 | Expressed | |
| MBL-1 | EOG77M8PC | MBNL2 | 1.00E-32 | Not assayed |
| EOG77M8PC | MBNL3 | 5.00E-31 | Expressed | |
| EOG77M8PC | MBNL1 | 5.00E-30 | Not assayed | |
| MTR-4 | EOG7XSTCX | SKIV2L2 | 0.0 | Expressed |
| RSP-3 | EOG76X620 | SRSF1 | 5.00E-56 | Expressed |
| EOG76X620 | SRSF9 | 3.00E-53 | Not assayed | |
| RSP-6 | EOG73NG5V | SRSF3 | 9.00E-23 | Expressed |
| EOG73NG5V | SRSF7 | 3.00E-22 | Expressed | |
| SET-2 | EOG72JWHB | SETD1A | 6.00E-65 | Expressed |
| EOG72JWHB | SETD1B | 7.00E-60 | Expressed | |
| SUP-26 | EOG71G9V3 | RBMS1 | 4.00E-53 | Expressed |
| EOG71G9V3 | RBMS2 | 8.00E-52 | Expressed | |
| EOG71G9V3 | RBMS3 | 9.00E-52 | Expressed | |
| Y55F3AM.3 | EOG71K63D | RBM39 | 3.00E-95 | Expressed |
| EOG71K63D | RBM23 | 3.00E-53 | Expressed |
Human orthologs were identified using the Database of Orthologous Groups and are displayed with the corresponding OrthoDB IDs. C. elegans proteins were aligned to the human protein RefSeq database using BLASTp and E values are given. Gene expression in the brain was determined using the TiGER database (Liu et al. 2008). RBP, RNA-binding protein; TiGER, Tissue-specific Gene Expression and Regulation.