Table 3. GO term analyses of transcriptional targets of H1: immune and stress response.
| GOTERM_BP_FAT | Count | P | Genes | Fold Enrichment |
|---|---|---|---|---|
| UP | ||||
| GO:0033554 cellular response to stress | 61 | 4.0E-11 | Debcl, Mms19, CG9272, lok, nod, CG31953, XRCC1, Top3alpha, Snm1, tefu, Ku80, Ubc6, okr, Pms2, msn, Rrp1, Rev1, spn-B, CG5524, spn-A, Lig4, dre4, mei-9, rad50, mre11, Btk29A, CG11403, Gen, mus210, CG2183, CG6812, p53, DNApol-eta, Jafrac1, mus209, pic, egr, puc, Irbp, pyd, hay, Xbp1, agt, mus205, CG5316, mus201, Ercc1, Fen1, rpr, Msh6, Ssrp, CG9203, Tfb4, spel1, Chrac-14, tos, CG11329, mu2, mus308, Corp, gkt, Src64B | 2.4 |
| GO:0006952 defense response | 42 | 8.3E-04 | CG10433, SPE, Sr-CI, Tollo, egr, IM10, Pmi, cactin, vir-1, CG16799, CG10345, IM3, IM1, Tsf1, PPO1, TotB, GNBP2, GNBP1, TotA, TotC, TotF, PGRP-SA, PGRP-SC2, Drs, Hf, PGRP-LD, He, CecC, Hml, kn, emp, LysX, ECSIT, CG33470, Ect4, AttD, psh, PGRP-SB2, Traf-like, TotZ, Tep3, Tep4, PGRP-LC, CG13422 | 1.7 |
| GO:0006955 immune response | 38 | 6.1E-03 | mus209, SPE, Sr-CI, Tollo, egr, IM10, CG3074, Pmi, vir-1, mbo, CG16799, IM3, IM1, PPO1, TotB, GNBP2, GNBP1, TotA, TotC, TotF, PGRP-SA, PGRP-SC2, Drs, Hf, PGRP-LD, CecC, He, Hml, kn, LysX, ECSIT, CG33470, Ect4, AttD, psh, PGRP-SB2, TotZ, dos, Tep4, PGRP-LC | 1.5 |
| GO:0009411 response to UV | 7 | 6.4E-03 | hay, TotZ, p53, TotB, TotA, TotC, TotF | 3.7 |
| GO:0009636 response to toxin | 8 | 4.9E-02 | Cyp4aa1, Ctp6a9, kraken, Cyp6a2, Cyp4ac1, Cyp12a4, GstE9, Cyp4ac2 | 2.3 |
| DOWN | ||||
| GO:0070301 cellular response to hydrogen peroxide | 5 | 2.2E-02 | Prx6005, Jafrac2, Prx2540-1, Pxn, Prx2540-2 | 4.3 |
Immunity-related, cellular defense and stress response genes that are regulated by H1 based on transcript profiling in salivary glands of H1-depleted L3 larvae (Lu et al. 2013) grouped in functional clusters. GOTERM_BP_FAT (lower levels of biological process ontology) terms are indicated. P values and fold enrichment were calculated using the NIH web-based tool DAVID. Only the GO term classes that exhibit P<0.05 for relative enrichment are shown. UP, genes upregulated more than two-fold in the H1 knockdown salivary glands relative to the control salivary glands; DOWN, genes downregulated more than two-fold.