Table 4.
Key laboratory data, overall and according to CV risk category in CAROLINA.
| Total (n = 6041)a | Group A: previous CV events (n = 2084) | Group B: retinopathy/albuminuria (n = 513) | Group C: age >70 years (n = 1163) | Group D: ⩾2 CV risk factors (n = 2252) | |
|---|---|---|---|---|---|
| HbA1c, % (mean ± SD) | 7.2 ± 0.6 | 7.2 ± 0.6 | 7.1 ± 0.6 | 7.1 ± 0.5 | 7.2 ± 0.6 |
| HbA1c ⩾ 8.0% (%) | 9.4% | 9.3% | 9.7% | 6.8% | 10.7% |
| Fasting plasma glucose, mg/dL (mean ± SD) | 140 ± 31 | 140 ± 31 | 139 ± 32 | 138 ± 29 | 141 ± 30 |
| BMI, kg/m2 (mean ± SD); ⩾35 kg/m2 (%) | 30.1 ± 5.1; 17.1% | 29.7 ± 5.0; 14.9% | 30.1 ± 5.3; 17.7% | 28.8 ± 4.6; 10.6% | 31.1 ± 5.3; 22.5% |
| Weight, kg (mean ± SD) | 84.0 ± 18.0 | 84.1 ± 17.7 | 82.4 ± 17.7 | 78.2 ± 15.8 | 87.2 ± 18.6 |
| Waist circumference, cm (mean ± SD) | 103 ± 13 | 103 ± 13 | 103 ± 14 | 101 ± 12 | 104 ± 13 |
| Systolic/diastolic BP, mmHg (mean ± SD) | 136 ± 16/79 ± 10 | 136 ± 17/78 ± 10 | 138 ± 18/79 ± 10 | 138 ± 16/77 ± 10 | 135 ± 15/81 ± 9 |
| Heart rate (mean ± SD) | 71 ± 11 | 69 ± 11 | 72 ± 11 | 70 ± 10 | 73 ± 10 |
| Lipids, mg/dL (mean ± SD) | |||||
| Total cholesterol | 177 ± 44 | 169 ± 43 | 182 ± 48 | 180 ± 40 | 181 ± 45 |
| LDL-cholesterol | 95 ± 36 | 90 ± 36 | 100 ± 38 | 98 ± 34 | 98 ± 35 |
| HDL-cholesterol | 48 ± 13 | 46 ± 12 | 49 ± 13 | 52 ± 14 | 48 ± 13 |
| Triglycerides (median, IQR) | 144 (105, 198) | 145 (105, 199) | 145 (109, 199) | 130 (99, 178) | 147 (109, 206) |
| eGFR according to MDRD, mL/min/1.73m2 (mean ± SD) | 77 ± 20 | 75 ± 19 | 63 ± 23 | 73 ± 17 | 84 ± 18 |
| eGFR according to MDRD (%) | |||||
| ⩾90 mL/min/1.73m2 | 23.4% | 19.9% | 13.8% | 15.0% | 33.3% |
| 60–<90 mL/min/1.73m2 | 57.5% | 58.3% | 30.8% | 64.7% | 59.6% |
| 30–<60 mL/min/1.73m2 | 18.2% | 21.4% | 52.8% | 19.7% | 6.8% |
| UACR, µg/mg; median (Q1, Q3) | 9.7 (5.3–30.9) | 10.6 (5.3–38.0) | 24.8 (7.1–108.3) | 9.7 (5.3–30.9) | 8.0 (4.4–20.3) |
| UACR (%) | |||||
| ⩽30 µg/mg | 74.0% | 71.0% | 53.0% | 74.2% | 82.1% |
| >30–300 µg/mg | 21.2% | 23.8% | 32.6% | 22.2% | 15.9% |
| >300 µg/mg | 4.3% | 5.1% | 14.2% | 3.5% | 1.8% |
IC: informed consent; T2D: type 2 diabetes; BP: blood pressure; SU: sulphonylurea; MI: myocardial infarction; MDRD: modified diet in renal disease; eGFR: estimated glomerular filtration rate; CV: cardiovascular; IQR: interquartile range; SD: standard deviation; UACR: urine albumin-to-creatinine ratio; LDL: low-density lipoprotein; HDL: high-density lipoprotein; BMI: body mass index.
n = 6019 for HbA1c, n = 6007 for fasting plasma glucose, n = 6016 for BMI, n = 6020 for weight and vital signs, n = 6015 for waist circumference, n = 6017 for eGFR, n = 6014 for UACR.
a
A few patients had no reliable CV risk categorization.