Table 7.
Chronology of end point assessment
| Chemotherapy cycle | 1 | 3 |
4 |
6 |
8 |
12 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Days | −7 | 0 | 28 | 30 | 42 | 44 | 70 | 72 | 98 | 100 | 154 |
| End points | |||||||||||
| Thermal (cold and hot) pain thresholds Vibrational detection thresholds |
X | X | X | X | X | X | X | X | X | X | X |
| Pain VAS | X | X | X | X | X | X | X | X | X | X | X |
| DN4-interview and NPSI questionnaires | X | X | X | X | X | X | X | X | X | X | X |
| HADS and QLQ-C30 questionnaires | X | X | X | X | X | X | X | ||||
| Polyamine level in erythrocytes | X | X | X | X | X | X | |||||
HADS, Hospitalised anxiety and depression scale; NPSI, Neuropathic pain symptoms inventory; QLQ-30, Quality of life questionnaire-core 30; VAS, visual analogue scale.