Table 4. Comparison of clinical features in 60 patients with t(8;21) according to c-KIT and WT1 mutation status.
| Variables | Patient subgroups | |||
|---|---|---|---|---|
| c-KIT(-)/WT1(-), N = 48 | c-KIT(+)/WT1(-), N = 5 | c-KIT(-)/WT1(+), N = 5 | c-KIT(+)/WT1(+), N = 2 | |
| Sex (M:F)* | 27:21 | 3:2 | 4:1 | 0:2 |
| Age, yr, median (range)† | 41.0 (5.0-78.0) | 42.0 (37.0-51.0) | 53.0 (18.0-64.0) | 18.5 (18.0-19.0) |
| Additional chromosomal abnormalities* | 12/48 (25.0%) | 0/5 (0.0%) | 1/5 (20.0%) | 0/2 (0.0%) |
| SCT during follow-up* | 18/48 (37.5%) | 3/5 (60.0%) | 0/5 (0.0%) | 1/2 (50.0%) |
| Relapse or death during follow-up* | 10/48 (20.8%) | 4/5‡ (80.0%) | 1/5 (20.0%) | 2/2 (100.0%) |
| Follow-up period, months, median (range)† | 30.5 (0.0-109.0) | 17.0 (6.0-35.0) | 35.0 (0.0-82.0) | 7.0 (4.0-10.0) |
| Laboratory findings at diagnosis† | ||||
| WBC ( × 109/L), median (range) | 8.62 (1.20-102.37) | 5.91 (2.90-8.40) | 10.70 (3.20-192.90) | 14.27 (3.20-25.33) |
| Hemoglobin (g/dL), median (range) | 8.5 (2.3-13.2) | 6.3 (5.6-8.4) | 8.4 (6.5-12.3) | 7.1 (5.4-8.7) |
| Platelets ( × 109/L), median (range) | 34.5 (3.0-155.0) | 24.0 (9.0-59.0) | 35.0 (8.0-59.0) | 21.5 (11.0-32.0) |
| PB blasts (%), median (range) | 23.0 (0.0-86.0) | 45.0 (13.0-54.0) | 52.0 (15.0-92.0) | 37.0 (27.0-47.0) |
| BM blasts (%), median (range) | 44.0 (21.0-90.0) | 58.0 (30.0-81.0) | 60.0 (21.0-89.0) | 62.0 (44.0-80.0) |
P values were obtained using Chi-square or Fisher's exact tests (for numbers less than five in each group)* and Mann-Whitney U test†. In patients without WT1 mutation, those with c-KIT mutation experienced relapse or died during follow-up more frequently than those without c-KIT mutation (P=0.014). Comparison items which showed statistically significant differences between two patient subgroups were indicated with superscript (‡).
Abbreviations: SCT, stem cell transplantation; WBC, white blood cell; PB, peripheral blood; BM, bone marrow; WT, Wilms' tumor.