Table 2. Laboratory and clinical characteristics of five renal allograft rejection patients with anti-AT1R-positive results.
Pt | Pt, Sex/age | pre-transplant | At the time of biopsy | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of HLA MM | CDC (T/B) | FCXM (T/B) | HLA Abs | DSA | desensitization | HTN | Anti-AT1R (U/mL) | HLA Abs | DSA | de-novo DSA | graft failure | ARB | Histological diagnosis | C4d | ||
1 | M/25 | 2 | N/N | N/N | N | N | N | P | 11.5 | N | N | N | N | N | Acute TCMR, type IA | N |
2 | M/25 | 6 | N/N | P/P | NA | NA | P | N | 10.1 | P | P | NA | N | N | Chronic active AMR, type II | P |
3 | M/40 | 2 | N/N | N/N | N | N | N | P | 17.5 | P | P | P | P | P | Chronic active AMR | P |
4 | F/53 | 2 | P/N | P/P | P | P | P | N | 10.3 | P | P | N | N | N | C4d-negative AMR, type II | N |
5 | F/43 | 6 | N/N | N/N | N | N | N | N | 11.2 | P | P | P | N | N | Acute TCMR, type IIA | P |
Acute AMR, type II |
Abbreviations: N, negative; P, positive; NA, not available; M, male; F, female; Pt, patients; CDC, complement dependent cytotoxicity crossmatch; FCXM, flow cytometry crossmatch; Abs, antibodies; HTN, hypertension; ARB, angiotensin II receptor blocker; DSA, donor specific HLA antibodies; AMR, antibody-mediated rejection; TCMR, T-cell-mediated rejection; MM, mismatch; T/B, T cell/B cell.