Table 5.
Number of studies meeting criteria for MCID
| Intervention | Control | MMSE |
ADAS-Cog | ||
|---|---|---|---|---|---|
| MD >1.4* | MD >2† | MD >3‡ | MD >4§ | ||
| CS | NA | 11/17 | 9/17 | 5/17 | 2/9 |
| ACTIVE | 2/3 | 0/3 | 0/3 | 0/0 | |
| CT | NA | 1/1 | 0/1 | 0/1 | 0/0 |
| ACTIVE | 1/3 | 1/3 | 0/3 | 0/0 | |
| MCTS | NA | 1/3 | 0/3 | 0/3 | 0/1 |
| ACTIVE | 1/3 | 0/3 | 0/3 | 0/1 | |
*Total number of studies reaching MCID of ≥1.4 MMSE points.
†Total number of studies reaching MCID of ≥2 MMSE points.
‡Total number of studies reaching MCID of ≥3 MMSE points. Of note only 5/17 CS versus NA studies and no CS versus active, CT or MCTS studies would reach a MCID of ≥3 MMSE.
§Total number of studies reaching MCID of ≥4 ADAS-Cog points.
ACTIVE, active control group; ADAS-Cog, Alzheimer's disease Assessment Scale-cognitive subscale; CS, cognitive stimulation; CT, cognitive training; MCTS, mixed cognitive stimulation and training; MCID, minimal clinically important difference; MD, mean difference calculated as (Mpostintervention−Mpreintervention)−(Mpostcomparator−Mprecomparator); MMSE, mini-mental state examination; NA, non-active control.