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. Author manuscript; available in PMC: 2016 Apr 6.
Published in final edited form as: Dev Cell. 2015 Apr 6;33(1):82–93. doi: 10.1016/j.devcel.2015.02.005

Figure 7. Structural comparison of HMP-2/pHMR-1cyto80 complex with SYS-1/POP-1 complex suggests why only HMP-2 can bind pHMR-1.

Figure 7

(A) Superposition of SYS-1/POP-1 (PDB ID 3C2G) into HMP-2/pHMR-1cyto80 complex. SYS-1 and POP-1 are colored light blue and cyan, respectively. Repeats 7 to 9 of SYS-1 and POP-1 are manually aligned to corresponding regions of HMP-2 and pHMR-1 in Coot. POP-1 (amino acids 8–14) aligns well with pHMR-1 region III, as shown in the close-up (boxed) view. SYS-1 and POP-1 residue numbers are in parentheses, and only those SYS-1 side chains that interact with POP-1 interaction are shown. Side chain of Glu9 of POP-1 is not modeled in the original structure. Hydrogen bonds in HMP-2/pHMR-1cyto80 and SYS-1/POP-1 complexes are shown as black and blue dotted lines, respectively.

(B) Repeats 5 and 6 of SYS-1 are aligned to corresponding region of HMP-2. Three arginine residues of HMP-2 interacting with pS1212 are not conserved in SYS-1.