Figure 1.

Structural dynamics of SERCA-PLB. (A) Initial and MD-relaxed structures of the SERCA-PLB complex embedded in a lipid bilayer (yellow) and water (blue). SERCA is colored according to its four functional domains: N (green), P (blue), A (red), and TM (gray). PLB is shown in magenta. (B) Time-dependent RMSD evolution of SERCA domains and full-length PLB in SERCA-PLB. The RMSD of the TM domain of SERCA and PLB was calculated using backbone alignment for TM helices of the pump. The RMSD of N, P, and A domains was calculated by aligning the backbone of the cytosolic headpiece with the structure at the beginning of each trajectory. To see this figure in color, go online.