Figure 4.

Water density maps of E1, E2, and E1⋅H⁺₇₇₁-PLB. (A) Water density map of E1 SERCA in various metal-bound states. (B) Water density of E2 SERCA. (C) Water density calculated for each individual MD trajectory of E1⋅H⁺₇₇₁-PLB. The blue surface represents the average weighted atomic density of water molecules using a grid resolution of 0.1 nm. The green and red boxes show the location of the cytosolic N-path and C-path, respectively. SERCA is shown as gray ribbons. To see this figure in color, go online.