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Coagulation cascade. Factors Xa and IIa (thrombin) are the principal targets for the new oral anticoagulants, while factors II, VII, IX, X, and protein C and S are decreased by the vitamin K antagonist, warfarin. Warfarin’s effect on the factor VIIa/TF complex is a possible cause of the increased intracranial bleeding seen in warfarin compared to the newer targeted agents.
