Table 1.

The large-scale pathogen–human PPI networks in chronological order.

Pathogen name	Pathogen type	Number of PHIs	Number of interacting pathogen proteins	Number of interacting human proteins	Reference
EBV	DNA virus	173	40	112	Calderwood et al. (2007)
HCV	RNA virus	481	11	421	De Chassey et al. (2008)
EBV	DNA virus	147	1	147	Forsman et al. (2008)
HIV-1	Retrovirus	183	1	183	Gautier et al. (2009)
Influenza A virus (H1N1 A/PR/8/34)	RNA virus	135	10	87	Shapira et al. (2009)
Influenza A virus (H3N2 A/Udorn/72)	RNA virus	81	10	66	Shapira et al. (2009)
Bacillus anthracis	Gram-positive bacteria	3,073	943	1,748	Dyer et al. (2010)
Yersinia pestis	Gram-positive bacteria	4,059	1,218	2,108	Dyer et al. (2010)
Francisella Tularensis	Gram-negative bacteria	1,383	349	999	Dyer et al. (2010)
HCV	RNA virus	56	2	56	Tripathi et al. (2010)
DENV	RNA virus	139	10	105	Khadka et al. (2011)
MV	RNA virus	245	1	245	Komarova et al. (2011)
Y. pestis	Gram-positive bacteria	204	66	109	Yang et al. (2011)
HIV-1	Retrovirus	497	16	435	Jäger et al. (2012)
30 viral species	DNA and RNA viruses	1681	70	579	Pichlmair et al. (2012)
HRSV	RNA virus	221	1	221	Wu et al. (2012)
HCV	RNA virus	112	7	94	Dolan et al. (2013)
HCV	RNA virus	103	1	103	Ngo et al. (2013)