Table 1.
Resource utilization
| 1a. | Time to extubation, hours | P value | |||
|---|---|---|---|---|---|
| Mean (SD) | Median (IQR) | ||||
| Dexmedetomidine | Standard care | Dexmedetomidine | Standard care | ||
| Pooled | 166.1 (219.5) | 195.1 (220.6) | 89.0 (46.0-188.0) | 118.0 (53.0-231.0) | 0.0003 |
| MIDEX | 183.8 (226.4) | 214.9 (229.3) | 95.0 (59.0-212.0) | 143.0 (75.0-232.0) | 0.0013 |
| PRODEX | 148.3 (211.3) | 175.1 (210.0) | 69.0 (39.0-164.0) | 91.0 (44.0-231.0) | 0.0405 |
| 1b. | Duration of mechanical ventilation, hours | P value | |||
| Mean (SD) | Median (IQR) | ||||
| Dexmedetomidine | Standard care | Dexmedetomidine | Standard care | ||
| Pooled | 192.7 (241.1) | 213.2 (229.1) | 103.0 (51.0-215.0) | 139.0 (70.0-265.0) | 0.0052 |
| MIDEX | 199.2 (237.5) | 231.4 (239.9) | 115.0 (66.0-216.0) | 146.5 (84.0-260.0) | 0.0047 |
| PRODEX | 186.3 (245.0) | 194.7 (216.7) | 94.0 (45.0-211.0) | 114.0 (47.0-266.0) | 0.2049 |
| 1c. | Duration of actual ICU stay, hours | P value | |||
| Mean (SD) | Median (IQR) | ||||
| Dexmedetomidine | Standard care | Dexmedetomidine | Standard care | ||
| Pooled | 271.3 (267.2) | 296.0 (265.6) | 166.5 (98.5-315.0) | 196.0 (116.0-361.0) | 0.0210 |
| MIDEX | 281.8 (265.0) | 318.4 (265.8) | 179.5 (115.0-341.0) | 217.0 (126.0-365.0) | 0.0131 |
| PRODEX | 260.8 (269.6) | 273.3 (265.0) | 146.0 (94.0-293.0) | 169.0 (93.0-355.0) | 0.4057 |
| 1d. | Cumulative sum of TISS points | P value | |||
| Mean (SD) | Median (IQR) | ||||
| Dexmedetomidine | Standard care | Dexmedetomidine | Standard care | ||
| Pooled | 360 (375) | 403 (360) | 239 (152-426) | 279 (177-503) | 0.0030 |
| MIDEX | 353 (328) | 419 (372) | 239 (157-428) | 300 (181-507) | 0.0094 |
| PRODEX | 368 (419) | 386 (347) | 242 (139-421) | 273 (170-501) | 0.1064 |
Duration of ventilator use (1a-b), intensive care unit (ICU) stay (1c), and cumulative sum of Therapeutic Intervention Scoring System (TISS) points (1d) are derived from MIDEX and PRODEX for the economic analysis. In MIDEX, the standard care sedative was midazolam; in PRODEX, it was propofol. IQR, interquartile range (first to third); SD, standard deviation.