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. 2014 Nov 18;6(1):27. doi: 10.1186/1868-7083-6-27

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© Zarfeshani et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of myostatin (MSTN) on AMP-activated protein kinase (AMPK) activity and glucose /lipid sensing in leucine- treated HepG2 cells. (A) Glucose uptake is repressed in MSTN-suppressed cells. MSTN knock-down efficiency using siRNA (B) The leucine- induced AMPK signaling pathway was suppressed following MSTN suppression. (C) mRNA levels of leucine-sensitive genes in the presence and absence of MSTN. Values are presented as the mean ± SEM. Statistical significance relative to untreated control, *P <0.05, **P <0.01 (n =3).