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. 2015 Mar 25;16(1):53. doi: 10.1186/s13059-015-0610-8

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© Manor and Borenstein; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The impact of MUSiCC on the discovery of differentially abundant genes. The number of genes identified as differentially abundant between (A) HMP stool samples and tongue dorsum samples, (B) type 2 diabetes (T2D) cases and controls, and (C) inflammatory bowel disease (IBD) cases and controls, are illustrated. Each Venn diagram describes the overlap between the set of genes identified when using standard compositional normalization (cyan, left) and the set of genes identified when using MUSiCC (maroon, right). Pathways that are over-represented in the set of genes identified by only one of the two methods are listed.