Table 2.
Schedule of visits and assessment
| Time point | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| D-14 to D-7 | D1 | D7 | D14 | D21 | D28 | D60 | D90 | D180 | D270 | D360 | |
| Informed consent | x | ||||||||||
| Allocation | x | ||||||||||
| Energetic and caloric needs assessment | x | x | x | -------------------------------------➔ 1 | |||||||
| Digestive symptoms and tolerance (individual notebook) | x | --------------------------------------------------------- ➔ 2 | |||||||||
| Functional status (Performance status, sit-up test, dynamometry, Weight, body-mass index, brachial circumference) | x | x | x | x | x | x | x | ||||
| Hepatic tolerance (Total bilirubin, free and conjugated bilirubin, AST, ALT, ALP, GGT) | x | x | x | x | x | x | x | x | x | x | |
| Transthyretin, C-reactive protein | x | x | x | x | -------------------------------------➔ 3 | ||||||
| Albumin | x | x | x | x | x | x | |||||
| Clinical assessment (GVHD, mucositis, infectious complications, red blood cells and platelets transfusions, catheter complications) | x | x | x | x | x | x | x | x | x | ||
| Chimerism | x | x | x | x | x | ||||||
| Quality of life (QLQ-C30) | x | x | x | x | |||||||
1Evaluated until hospital discharge; 2Auto-evaluated daily during nutritional intervention; 3Evaluated once per week until hospital discharge; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyltransferase.