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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Nat Commun. 2015 Apr 7;6:6613. doi: 10.1038/ncomms7613

Figure 8. Model of hair cell regeneration in the neonatal mouse utricle.

Figure 8

Striolar supporting cells (SCs) express Lgr5 after hair cell (HC) ablation in vitro and in vivo (16.8 and 28.5%, respectively). After neomycin-induced HC loss, Lgr5+ SCs regenerate HCs via direct transdifferentiation in vitro. After HC ablation in vivo, Lgr5+ SCs regenerate HCs using both mitotic and non-mitotic mechanisms. Activating Wnt signaling promotes mitotic HC regeneration.