Following 110 days of hypoxic acclimatization, reactivity to electrical nerve stimulation in ovine fetal cerebral arteries was significantly enhanced compared to normoxic controls. Conversely, hypoxic acclimatization modestly depressed contractile reactivity to nerve stimulation in adult cerebral arteries. Results are presented as mean ± SEM. For fetal normoxic (FN), fetal hypoxic (FH), and adult normoxic (SNC) groups, N=16. For the adult hypoxic group (SHC), N=21.