Table 1.

Methodological aspects, design and quality of studies, and characterization of groups.

Primary author	Study design and blinding type	Primary outcome	Sample allocation and profile	Sample loss and calculation	Test product masking	Pilot study and examiner calibration	Control group characterization	Test product pharmaceutical form, concentration, and usage time
Wright [13]	Randomized controlled clinical trial. Study was not blind.	Treatment of oral candidiasis: clinical regression of lesions.	90 patients with HIV/AIDS in a sanatorium. These patients were diagnosed with oral candidiasis and were not being treated for this purpose. Not mentioned: sample allocation.	The study began with 90 patients and finished with 52. Not mentioned: calculation.	There was no masking.	Not mentioned: pilot study and examiner calibration.	Gentian violet aqueous solution (0.5%). Painted on the inside of the mouth three times daily for 10 days.	Lemon juice (experimental treatment 1) for 10 days or until clinical cure; lemon grass (experimental treatment 2) for 10 days. Not mentioned: concentrations.
Bakhshi [3]	Controlled randomized double-blind clinical trial. Not mentioned: the blinding of study subjects.	Treatment of stomatitis under denture: clinical reduction of lesions after mouthwash.	40 institutionalized elderly subjects diagnosed with denture stomatitis. Not mentioned: sample allocation.	Not mentioned: calculation and loss.	Garlic aqueous solution and nystatin mouthwash were in similar bottles with the same shape, size, and color. Not mentioned: masking of smell, color, and taste.	Not mentioned: pilot study and examiner calibration.	Nystatin mouthwash (100,000 U/mL). Swish 20 drops for 60 seconds, three times a day.	Garlic aqueous solution (40 mg/mL) for 4 weeks.
Amanlou [2]	Randomized controlled triple-blind clinical trial.	Treatment of stomatitis under denture associated with Candida: reduction of clinical signs and symptoms and microbiological findings.	24 users of dentures diagnosed with denture stomatitis (clinical and microbiological), aged between 45 and 83 years. Not mentioned: sample allocation.	Not mentioned: calculation and loss.	Masking of smell, color, and taste as much as possible.	Not mentioned: pilot study and examiner calibration.	Miconazole 2% gel. Apply 2.5 mL on the base of the denture and place it in, four times a day for a period of 2 weeks.	Z. multiflora essential oil 0.1% gel for 2 weeks.