Table 1.

Performance of gene-level methods

Group	Method	Sensitivity (%)	Specificity (%)	False positives (%)	False negatives (%)
Classical	Fisher	59.18	88.64	5.89	40.82
	Sidak	18.37	97.73	0.11	81.63
	Simes	46.94	97.73	1.33	53.06
	FDR	24.49	97.73	0.13	75.51
Updated Classical	TPM	63.04	92.86	4.93	36.96
	GATES	24.49	98.00	0.17	75.51
	WGATES	26.53	98.00	0.16	73.47
	HYST	24.49	98.00	0.16	75.51
	WHYST	24.49	98.00	0.16	75.51
Novel	VEGAS	20.41	100.0	0.16	79.59
	VEGAS [10%]	28.57	98.00	0.40	71.43