Table 4.

Cumulative responses recorded 1–5 min after injection of fentanyl in vehicle-, naloxone- or naloxone-methiodide-treated rats

	NLX Study		NLXmi Study
Parameter	Vehicle	NLX	Vehicle	NLXmi
Frequency (breaths/min) x min	88 ± 18*	196 ± 19*, †	200 ± 39*	−164 ± 18*,†
Tidal Volume (mls) x min	−2.53 ± 0.43*	0.26 ± 0.14†	−4.27 ± 0.52*	−1.49 ± 0.30*,†
Minute Ventilation (mls/min) x min	−454 ± 58*	441 ± 36*,†	−604 ± 73*	−471 ± 66*
Inspiratory Time (sec) x min	0.30 ± 0.08	−0.27 ± 0.03*,†	0.26 ± 0.06*	0.68 ± 0.09*,†
Expiratory Time (sec) x min	−0.00 ± 0.06	−0.12 ± 0.06	−0.19 ± 0.08	0.20 ± 0.13
End Inspiratory Pause (msec) x min	19 ± 3*	−8 ± 3†	13 ± 1	16 ± 2
Peak Inspiratory Flow (mls/sec) x min	−50 ± 5*	56 ± 9*,†	−53 ± 6*	−38 ± 5*
Peak Expiratory Flow (mls/sec) x min	−23 ± 8	68 ± 10*,†	−19 ± 7	−16 ± 8

Data are presented as mean ± SEM. NLX, naloxone. NLXmi, naloxone methiodide. There were 6 rats in each group.

^*P < 0.05, significant Response Area.

^†P < 0.05, NLX or NLXmi versus relevant vehicle.