Table 5.

Cumulative responses recorded 6–20 min after injection of fentanyl in vehicle-, naloxone- or naloxone-methiodide-treated rats

	Naloxone Study		Naloxone methiodide Study
Parameter	Vehicle	NLX	Vehicle	NLXmi
Frequency (breaths/min) x min	−582 ± 69*	246 ± 38*,†	−435 ± 51*	−502 ± 60*
Tidal Volume (mls) x min	2.14 ± 0.56	−0.13 ± 0.18	4.06 ± 0.52*	5.04 ± 0.58*
Minute Ventilation (mls/min) x min	−679 ± 73*	455 ± 67*,†	−444 ± 53*	−337 ± 46*
Inspiratory Time (sec) x min	2.27 ± 0.36*	−0.25 ± 0.08†	2.25 ± 0.37*	1.80 ± 0.29*
Expiratory Time (sec) x min	0.13 ± 0.06	−0.16 ± 0.08	−0.15 ± 0.06	−0.20 ± 0.07
End Inspiratory Pause (msec) x min	121 ± 17*	−9 ± 6	109 ± 15*	66 ± 9*,†
Peak Inspiratory Flow (mls/sec) x min	−141 ± 13*	20 ± 3*,†	−91 ± 9*	−78 ± 9*
Peak Expiratory Flow (mls/sec) x min	24 ± 3*	1 ± 6*,†	28 ± 4*	18 ± 4*

Data are presented as mean ± SEM. NLX, naloxone. NLXmi, Naloxone methiodide. There were 6 rats in each group. P < 0.05, significant Response Area.

^†P < 0.05, NLX or NLXmi versus relevant vehicle.