Table 6.

Summary of the effects of naloxone and naloxone methiodide on fentanyl-induced responses

	Fentanyl Responses		Effects of Antagonists
Parameter	Direction	Duration (min)	NLX	NLXmi
Frequency	↑*↓	1–5, 6–20	+++	0
Tidal Volume	↓	5	+++	++
Minute Ventilation	↓	20	+++	0
Inspiratory Time	↑	20	+++	0
Expiratory Time	≈0	n.a.	n.a.	n.a.
End Inspiratory Pause	↑	> 20	+++	+
Peak Inspiratory Flow	↓	20	+++	0
Peak Expiratory Flow	↓	4	+++	0

NLX, naloxone. NLXmi, naloxone methiodide. +++ to +, complete to partial blockade; 0, no effect; n.a., not applicable.