Table 2.
Detection of individual high-risk and low-risk HPV genotypes by CLART and LA in 401 women with abnormal cytology
| Genotype | Prevalence | Agreement | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CLART, N (%) | LA, N (%) | Relative prevalence CLART vs. LA (95% CI) | CLART+/LA+ | CLART+/LA- | CLART-/LA+ | CLART-/LA- | Total agreement (95% CI) | Positive agreement (95% CI) | |
| High-risk | |||||||||
| 16 | 121 (30%) | 126 (31%) | 0.96 (0.78-1.18) | 120 (30%) | 1 (0%) | 6 (1%) | 274 (68%) | 98% (96-99) | 94% (89-98) |
| 18 | 45 (11%) | 53 (13%) | 0.85 (0.59-1.23) | 45 (11%) | 0 (0%) | 8 (2%) | 348 (87%) | 98% (96-99) | 85% (72-93) |
| 31 | 64 (16%) | 61 (15%) | 1.05 (0.76-1.45) | 61 (15%) | 3 (1%) | 0 (0%) | 337 (84%) | 99% (98-100) | 95% (87-99) |
| 33 | 42 (10%) | 40 (10%) | 1.05 (0.70-1.58) | 39 (10%) | 3 (1%) | 1 (0%) | 358 (89%) | 99% (97-100) | 91% (78-97) |
| 35 | 19 (5%) | 16 (4%) | 1.19 (0.62-2.28) | 16 (4%) | 3 (1%) | 0 (0%) | 382 (95%) | 99% (98-100) | 84% (60-97) |
| 39 | 22 (5%) | 48 (12%) | 0.46 (0.28-0.74) | 22 (5%) | 0 (0%) | 26 (6%) | 353 (88%) | 94% (91-96) | 46% (31-61) |
| 45 | 16 (4%) | 35 (9%) | 0.46 (0.26-0.81) | 16 (4%) | 0 (0%) | 19 (5%) | 366 (91%) | 95% (93-97) | 46% (29-63) |
| 51 | 47 (12%) | 50 (12%) | 0.94 (0.65-1.37) | 46 (11%) | 1 (0%) | 4 (1%) | 350 (87%) | 99% (97-100) | 90% (79-97) |
| 52 | 49 (12%) | 40 (10%) | 1.23 (0.83-1.82) | 33 (8%) | 16 (4%) | 7 (2%) | 345 (86%) | 94% (92-96) | 59% (45-72) |
| 56 | 30 (7%) | 39 (10%) | 0.77 (0.49-1.21) | 27 (7%) | 3 (1%) | 12 (3%) | 359 (90%) | 96% (94-98) | 64% (48-78) |
| 58 | 59 (15%) | 40 (10%) | 1.48 (1.01-2.15) | 38 (9%) | 21 (5%) | 2 (0%) | 340 (85%) | 94% (92-96) | 62% (49-74) |
| 59 | 27 (7%) | 29 (7%) | 0.93 (0.56-1.54) | 20 (5%) | 7 (2%) | 9 (2%) | 365 (91%) | 96% (94-98) | 56% (38-72) |
| 68 | 25 (6%) | 16 (4%) | 1.56 (0.85-2.88) | 6 (1%) | 19 (5%) | 10 (2%) | 366 (91%) | 93% (90-95) | 17% (7-34) |
| Low-risk | |||||||||
| 6 | 15 (4%) | 13 (3%) | 1.15 (0.56-2.39) | 12 (3%) | 3 (1%) | 1 (0%) | 385 (96%) | 99% (97-100) | 75% (48-93) |
| 11 | 4 (1%) | 4 (1%) | 1.00 (0.25-3.97) | 4 (1%) | 0 (0%) | 0 (0%) | 397 (99%) | 100% (99-100) | 100% (40-100) |
| 26 | 3 (1%) | 3 (1%) | 1.00 (0.20-4.93) | 3 (1%) | 0 (0%) | 0 (0%) | 398 (99%) | 100% (99-100) | 100% (29-100) |
| 40 | 5 (1%) | 6 (1%) | 0.83 (0.26-2.71) | 5 (1%) | 0 (0%) | 1 (0%) | 395 (99%) | 100% (99-100) | 83% (36-100) |
| 42 | 20 (5%) | 28 (7%) | 0.71 (0.41-1.25) | 20 (5%) | 0 (0%) | 8 (2%) | 373 (93%) | 98% (96-99) | 71% (51-87) |
| 53 | 50 (12%) | 52 (13%) | 0.96 (0.67-1.38) | 48 (12%) | 2 (0%) | 4 (1%) | 347 (87%) | 99% (97-99) | 89% (77-96) |
| 54 | 15 (4%) | 36 (9%) | 0.42 (0.23-0.75) | 14 (3%) | 1 (0%) | 22 (5%) | 364 (91%) | 94% (92-96) | 38% (22-55) |
| 61 | 34 (8%) | 44 (11%) | 0.77 (0.50-1.18) | 34 (8%) | 0 (0%) | 10 (2%) | 357 (89%) | 98% (95-99) | 77% (62-89) |
| 62 | 12 (3%) | 30 (7%) | 0.40 (0.21-0.77) | 12 (3%) | 0 (0%) | 18 (4%) | 371 (93%) | 96% (93-97) | 40% (23-59) |
| 66 | 44 (11%) | 40 (10%) | 1.10 (0.73-1.65) | 37 (9%) | 7 (2%) | 3 (1%) | 354 (88%) | 98% (95-99) | 79% (64-89) |
| 70 | 28 (7%) | 24 (6%) | 1.17 (0.69-1.98) | 24 (6%) | 4 (1%) | 0 (0%) | 373 (93%) | 99% (97-100) | 86% (67-96) |
| 71 | 1 (0% | 2 (0%) | 0.50 (0.05-5.49) | 0 (0%) | 1 (0%) | 2 (0%) | 398 (99%) | 99% (98-100) | 0% (0-71) |
| 72 | 1 (0%) | 1 (0%) | 1.00 (0.06-15.93) | 1 (0%) | 0 (0%) | 0 (0%) | 400 (100%) | 100% (99-100) | 100% (3-100) |
| 73 | 11 (3%) | 31 (8%) | 0.35 (0.18-0.70) | 11 (3%) | 0 (0%) | 20 (5%) | 370 (92%) | 95% (92-97) | 35% (19-55) |
| 81 | 12 (3%) | 14 (3%) | 0.86 (0.40-1.83) | 12 (3%) | 0 (0%) | 2 (0%) | 387 (97%) | 100% (98-100) | 86% (57-98) |
| 82 | 47 (12%) | 21 (5%) | 2.24 (1.36-3.67) | 20 (5%) | 27 (7%) | 1 (0%) | 353 (88%) | 93% (90-95) | 42% (28-57) |
| 83 | 15 (4%) | 14 (3%) | 1.07 (0.52-2.19) | 12 (3%) | 3 (1%) | 2 (0%) | 384 (96%) | 99% (97-100) | 71% (44-90) |
| 84 | 15 (4%) | 26 (6%) | 0.58 (0.31-1.07) | 15 (4%) | 0 (0%) | 11 (3%) | 375 (94%) | 97% (95-99) | 58% (37-77) |