Table I.
Association of IL-6 expression with clinical characteristics in OSCC.
| Clinical factors | Cases (%) | IL-6 expression
|
P-value | ||
|---|---|---|---|---|---|
| Negative | Low | High | |||
| Gender | N.S. | ||||
| Male | 52 (66.7) | 16 | 12 | 24 | |
| Female | 26 (33.3) | 8 | 10 | 8 | |
| Primary site | N.S. | ||||
| Tongue | 42 (53.9) | 14 | 15 | 13 | |
| Gingiva | 26 (33.3) | 7 | 5 | 14 | |
| Buccal mucosa | 7 (9.0) | 2 | 1 | 4 | |
| Oral floor | 3 (3.8) | 1 | 1 | 1 | |
| Clinical stage | P<0.05 | ||||
| I and II | 42 (53.8) | 17 | 14 | 11 | |
| III and IV | 36 (46.2) | 7 | 8 | 21 | |
| Clinical T stage | N.S. | ||||
| T1/T2 | 50 (64.1) | 20 | 15 | 15 | |
| T3/T4 | 28 (35.9) | 4 | 7 | 17 | |
| Nodal metastasis | P<0.05 | ||||
| Yes | 35 (44.9) | 7 | 7 | 21 | |
| No | 43 (55.1) | 17 | 15 | 11 | |
| Local recurrence | N.S. | ||||
| Yes | 14 (17.9) | 3 | 2 | 9 | |
| No | 64 (82.1) | 21 | 20 | 23 | |
| Distant metastasis | P<0.05 | ||||
| Yes | 5 (6.4) | 0 | 0 | 5 | |
| No | 73 (93.6) | 24 | 22 | 27 | |
| Histologic grade | N.S. | ||||
| Grade 1 | 29 (37.2) | 7 | 9 | 13 | |
| Grade 2 | 49 (62.8) | 17 | 13 | 19 | |
| Mode of invasion | N.S. | ||||
| Grade 1/2/3 | 61 (78.2) | 19 | 17 | 25 | |
| Grade 4C/4D | 17 (21.8) | 5 | 5 | 7 | |
Values expressed as a number of patients. Chi-squared test are used to assess the significant differences between each group. N.S., not significant.