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Relative volume change in human HCT116 colorectal tumors (A) and body weight change in HCT116 tumor-bearing nude mice (B). Mice were treated with vehicle (○), TAS-102 (□), bevacizumab (△), or combined TAS-102 and bevacizumab (▲). The values indicate the means + SD (n=6). The horizontal dotted line indicates an RTV of 5. RTV, relative tumor volume.
