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. 2015 Apr 2;12:64. doi: 10.1186/s12974-015-0283-y

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© Li et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Neuregulin-1 inhibits DFP-induced changes in microglial morphology in the hippocampus. Brains collected 24 h post-DFP administration were immunostained for CD11b to identify microglia in the hippocampus, and a subset of these sections was also stained for DAPI (C, D). CD11b immunopositive cells with morphological characteristics of activated microglia (indicated by arrows) were seen in the hippocampus 24 h following DFP administration (A, C). In contrast, CD11b immunopositive cells in the hippocampus of DFP intoxicated animals treated with NRG-1 exhibited morphologies characteristic of resting microglia (B, D). H, hilus; GL, granule cell layer. Stereotaxic coordinate = bregma −3; Scale bar = 50 μm.