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ATF4 increases the microvascular density in breast cancer tissue. (a) Immunofluorescence staining of CD31 showed the increased microvascular density in ATF4-overexpressing 4T1-Luc breast cancers. (b) Immunofluorescence staining of CD31 showed the increased microvascular density in ATF4-overexpressing 4TO7 breast cancers. (c) ATF4 did not significantly influence the expression of proangiogenic factors.
