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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Science. 2014 Dec 19;346(6216):1486–1492. doi: 10.1126/science.346.6216.1486

Figure 1. Cytosolic DNA and RNA sensing pathways are essential for induction of the TI-2 antibody response.

Figure 1

(A) Serum NP-specific IgM on day 4.5 post-immunization with NP-Ficoll. (B) Serum NP-specific IgM on day 4.5 post-immunization with NP-LPS. (C) Serum βgal-specific IgG on day 14.5 post-immunization with rSFV-encoded βgal. (D) Serum NP-specific IgM on day 4.5 post-immunization of Rag2−/− mice adoptively transferred 1 day prior to immunization with splenic and peritoneal B cells from donor mice of the indicated genotypes. Data points represent individual mice. P values were determined by one-way ANOVA and post hoc Tukey test; in B and C, no significant difference was found between any mutant genotype and C57BL/6J. Results are representative of 2–3 independent experiments.