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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Cell Rep. 2012 Sep 20;2(3):488–496. doi: 10.1016/j.celrep.2012.08.022

Figure 1. Inflammation-Induced Impairment of Contextual Fear Memory Is Absent in Gabra5−/− Mice and Can Be Prevented by Pharmacological Inhibition of α5GABAA Receptor in WT Mice.

Figure 1

(A) IL-1β reduced the freezing scores for contextual fear memory only in WT mice. The bar graph shows the summarized results.

(B) L-655,708 or MRK-016 restored the freezing scores for contextual fear memory to control values in WT mice.

(C) LPS reduced the freezing scores for contextual fear memory only in WT mice, and L-655,708 restored the freezing scores to control values in WT mice.

(D) IL-1β did not affect the freezing scores for cued fear memory in response to tone in both WT and Gabra5−/− mice. Data are represented as mean ± SEM. Here and in subsequent figures, Con stands for control. *p < 0.05, **p < 0.01, ***p < 0.001, N.S.: nonsignificant result. See also Figure S1.