Figure 2. Radiographic Findings Before PMD Therapy.

At age 3 years, the skeleton shows features consistent with OPT. These include diffuse osteosclerosis and hyperostosis, a skull base that is very sclerotic (a), laterally bowed femora (b), mild modeling abnormalities including an Erlenmeyer flask deformity of the proximal humerus (c), diffusely sclerotic spine (d), and femoral medullary cavities narrowing and thick cortices (e).