Table 1.
Natural health products that target the angiogenesis pathways.
| NHPs/NPs | Target (decrease) |
|---|---|
| Artemisia annua (artemisinin) | VEGF/KDR |
| Camellia sinensis (epigallocatechin) | VEGF protein kinase C |
| Chrysobalanus icaco (methanol extract) | |
| Curcuma longa (curcumin) | MMP-2/9 VEGF bFGF CD13 (aminopeptidase N) |
| Ginkgo biloba (ginkgolide B) | VEGF |
| Magnolia obovata (honokiol) | PGDF TGF β |
| Polygonum cuspidatum (resveratrol) | MMP-2 VEGF |
| Quercetin | COX-2 lipoxygenase-5 enzymes EGFR |
| Scutellaria baicalensis (baicalin and baicalein) | VEGF bFGF 12-lipoxygenase activity MMP |
| Silybum marianum (silymarin) | VEGF |
| Viscum album (lectins) | VEGF |
| Squalus acanthias (dogfish liver: squalamine) | HER2 |
| Soy isoflavones (genistein, daidzein) | EGFR (HER1) |
| Aloe barbadensis (aloe vera leaf and pulp extracts) | HER2/neu |
| Omega-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid) | COX-2 lipoxygenase-5 enzymes EGFR |
| Ocimum sanctum (carnosol, ursolic acid) | COX-2 NF-κB several tyrosine kinases EGFR |
| Rosmarinus officinalis (carnosol and ursolic acid) | COX-2 NF-κB several tyrosine kinases EGFR |
| Zingiber officinale (6-gingerol) | COX-2 NF-κB |