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. 2015 Feb 23;17(1):35. doi: 10.1186/s13075-015-0538-0

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© Hadaschik et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Transfer of scurfy CD4 ⁺ T cells induces skin, lung and kidney pathology in B6/nude mice . Four weeks after transfer of purified CD4⁺ T cells from scurfy (Sc) and wild-type (WT) mice into immunocompromised B6/nude mice, tissues were analyzed by histology. All recipients of scurfy CD4⁺ T cells showed severe skin inflammation (a and b) and lung inflammation (c and d), whereas recipients of WT CD4⁺ T cells and PBS-treated recipients did not. Kidney pathology was observed in two of seven recipients of scurfy CD4⁺ T cells, but in none of the controls (e).