Table 2.
General characteristics and plasma parameters of experimental rats at the end of week 12.
| ND | ND + CGE | DM | DM + CGE | DM + metformin | |
|---|---|---|---|---|---|
| General characteristic | |||||
| BW (g) | 430.0 ± 26.5 | 420.5 ± 20.3 | 456.3 ± 30.9 | 426.7 ± 30.6 | 416.7 ± 66.6 |
| KW/BW | 5.7 ± 0.8 | 6.0 ± 0.7 | 5.6 ± 0.9 | 6.2 ± 1.0 | 5.9 ± 1.0 |
| Plasma parameter | |||||
| Glucose (mg/dL) | 135.1 ± 19.9 | 128.3 ± 15.6 | 301.0 ± 20.2* | 149.2 ± 53.8# | 164.8 ± 38.0# |
| Triglyceride (mmol/L) | 140.4 ± 44.4 | 121.5 ± 24.7 | 286.7 ± 49.5* | 142.6 ± 32.0# | 156.5 ± 40.9# |
| Insulin (ng/mL) | 2.8 ± 1.1 | 2.3 ± 0.4 | 1.8 ± 0.9 | 1.7 ± 0.8 | 1.1 ± 0.7 |
| HOMA index | 16.4 ± 4.1 | 13.4 ± 4.8 | 28.4 ± 15.1* | 12.7 ± 4.6# | 15.9 ± 2.6# |
Data are presented as mean ± SD from 6 to 8 animals per group. BW: body weight; KW: kidney weight; HOMA: homeostatic model assessment of insulin resistance; * P < 0.05 indicates the significant differences from normal (ND) and # P < 0.05 indicates the significant differences from T2DM (DM) rats.