. Author manuscript; available in PMC: 2015 Apr 9.

Published in final edited form as: Curr HIV Res. 2012 Jan 1;10(1):9–18. doi: 10.2174/157016212799304625

Table 2.

Non-Specific Microbicide Candidates Currently in Development^*

Product	Mechanism of Action/Targets	Stage of Development	References
VivaGel (SPL7013 dendrimer)	Attachment/Entry Inhibitor; HIV/HSV	Clinical	[104–110]
Praneen (Polyherbal Tablet)	HIV/Pregnancy; Possibly HSV	Clinical	[111–116]
Zinc Acetate (±MIV-150) in Carrageenan Gel	Antiviral/Virucidal/Immunomodulatory; HIV/HSV	Pre-Clinical	[138]
Aptamers	Attachment/Entry Inhibitor; HIV/HSV	Pre-Clinical	[149,150]
Aptamers-siRNA Hybrid	CCR5 knockdown; HIV/HSV	Pre-Clinical	[151]
Sydencan-Fc Hybrid	Attachment/Entry Inhibitor; HIV/HSV	In vitro	[152]
Monoclonal Antibodies	Broadly Neutralizing; HIV/HSV	Pre-Clinical	[153–155]

This is a partial listing of non-specific, broad spectrum microbicide candidates currently in development, and does not include non-ARV, anti-HIV compounds also in development (e.g., [156,157]).