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. 2015 Apr 9;10(4):e0124535. doi: 10.1371/journal.pone.0124535

Table 2. Grading of Recommendations, Assessment, and Evaluation (GRADE) ranking for evidence of two outcomes.

No of studies Risk of bias Inconsistency Indirectness Imprecision Other considerations Ortho-k Control Mean Difference Quality Importance
7 studies 1 Serious 3 No serious inconsistency No serious indirectness No serious imprecision None 218 217 0.27 (CI: 0.32 to 0.22) Moderate Critical
2 studies 2 Serious 3 No serious inconsistency No serious indirectness No serious imprecision None 63 63 0.22 (CI: 0.31 to 0.14) Moderate Critical

1 Axial length (follow-up mean 2 years; better indicated by lower values).

2 Vitreous chamber length (follow-up mean 2 years; better indicated by lower values).

3 Most of studies did not use blinding method.