Table 2.
Absolute and relative changes in body composition, areal BMD, volumetric BMD, bone strength, bone markers, parathyroid hormone (PTH), 25-hydroxy (25-OH) vitamin D and aerobic power in response to the exercise-induced weight loss intervention (n=14).
| Baseline | 4 Months | Mean Change (95% CI) (% Change) | p value | |
|---|---|---|---|---|
| Body Composition (kg) | ||||
| Total Mass | 83.8±16.0 | 80.9±16.8 | −3.0 (−4.40,−1.39) (−3.7%) | 0.001 |
| Fat Mass | 34.8±9.2 | 32.5±10.0 | −2.3 (−3.49,−1.09) (−7.3%) | 0.001 |
| Fat-free Mass | 49.0±7.5 | 48.4±7.7 | −0.6 (−1.26,0.05) (−1.3%) | 0.07 |
|
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| Areal BMD (g/cm2f) | ||||
| Hip | 0.952±0.152 | 0.942±0.155 | −0.010 (−0.020,0.001) (−0.1%) | 0.07 |
| Femoral Neck | 0.789±0.129 | 0.788±0.135 | −0.001 (−0.014,0.013) (−1.1%) | 0.94 |
| Trochanter | 0.719±0.134 | 0.711±0.138 | −0.008 (−0.019,0.003) (−1.3%) | 0.13 |
| Subtrochanter | 1.129±0.173 | 1.117±0.176 | −0.011 (−0.025,0.003) (−1.0%) | 0.10 |
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| Volumetric BMD (g/cm3) | ||||
| Total Hip | 290.0±50.0 | 287.1±42.6 | −2.9 (−14.5,8.7) (−0.5%) | 0.60 |
| Cortical | 860.1±55.4 | 841.7±71.8 | −18.4 (−51.9,15.0) (−2.1%) | 0.26 |
| Trabecular | 132.9±25.3 | 132.7±22.2 | −0.2(−5.5,5.0) (0.3 %) | 0.93 |
| Total Neck | 287.2±57.8 | 288.6±48.9 | 1.4 (−13.7,16.5) (1.2 %) | 0.84 |
| Cortical | 922.6±105.0 | 909.2±109.9 | −13.4 (−68.3,41.4) (−1.1%) | 0.61 |
| Trabecular | 129.4±22.4 | 128.2±19.5 | 1.3 (−6.3,3.8) (−0.6%) | 0.60 |
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| Bone Strength (Femoral Neck) | ||||
| CSMImax (mgxcm) | 3406±2710 | 1944±594 | −1462 (−3085,160) (−19.0%) | 0.07 |
| SMmax(cm3) | 7.0±4.0 | 4.6±0.8 | −2.4 (−4.8,−0.1) (−17.4%) | 0.05 |
| CSMImin (mgxcm) | 1725±560 | 1565±510 | −159(−459, 140) (−5.4%) | 0.27 |
| SMmin (cm3) | 5.0±1.4 | 4.5±0.8 | −0.6 (−1.4, 0.2) (−7.1%) | 0.12 |
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| Bone Markers | ||||
| CTX (ng/mL) | 0.5±0.2 | 0.6±0.2 | 0.1 (−0.1,0.2) (20.1%) | 0.37 |
| BAP (U/L) | 25.4±7.0 | 25.2±6.4 | −0.2 (−1.7,1.3) (−0.1%) | 0.76 |
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| PTH (pg/mL) | 45.1±6.8 | 41.0±11.8 | −4.1 (−11.6,3.4) (−7.5%) | 0.26 |
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| Vitamin D (25OH) (ng/mL) | 28.1±10.9 | 30.6±10.3 | 2.43(−1.7,6.6) (14.0%) | 0.22 |
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| Maximal Aerobic Power | ||||
| VO2 (mL/kg/min) | 25.4±3.6 | 29.3±5.4 | 3.9 (1.5, 6.3) (15.9%) | 0.004 |
| VO2 (L/min) | 2.12±0.41 | 2.35±0.44 | 0.23 (0.08, 0.38) (11.8%) | 0.006 |
P values are based on a paired t test. BMD: bone mineral density; CSMImax: cross-sectional moment of inertia, strong axis of bone; CSMImin: cross-sectional moment of inertia, weak axis of bone; Zmax: section modulus, strong axis of bone; Zmin: section modulus, weak axis of bone.