Table 3.

Absolute changes in body composition, areal BMD, volumetric BMD, bone strength, bone markers, parathyroid hormone (PTH) and 25-hydroxy (25-OH) vitamin D for weight loss and weight stable participants (0 to 4 months).

	4 Month Change		Difference (95% CI)	* p value
	Weight Loss (N=14)	Weight Stable (N=10)
Body Composition (kg)
Total Mass	−3.0±2.61	0.3±1.88	−3.2 (−5.11, −1.31)	0.002
Fat Mass	−2.3±2.08	0.4±1.37	−2.7 (−4.20, −1.27)	<.001
Fat Free Mass	−0.6±1.14	−0.1±1.08	−0.5 (−1.43, 0.48)	0.31
Areal BMD (g/cm2)
Hip	−0.001±0.024	−0.011±0.019	0.001 (−0.015, 0.017)	0.86
Femoral Neck	−0.010±0.018	0.01±0.020	−0.009 (−0.028, 0.009)	0.31
Trochanter	−0.008±0.019	−0.009±0.020	0.001 (−0.016, 0.017)	0.94
Subtrochanter	−0.011±0.024	−0.012±0.021	0.001 (−0.018, 0.021)	0.90
Volumetric BMD (g/cm3)
Total Hip	−2.9±20.1	−8.3±21.9	5.4 (−13.0, 23.8)	0.54
Cortical	−18.4±58.0	−25.8±66.5	7.4 (−47.5, 62.3)	0.78
Trabecular	−0.2±9.1	−3.5±10.6	3.3 (−5.4, 12.0)	0.44
Total Neck	1.4±26.1	−9.6±27.6	11.0 (−12.4, 34.4)	0.34
Cortical	−13.4±95.0	−4.5±81.2	−8.9 (−84.0, 66.1)	0.81
Trabecular	−1.2±8.7	−1.7±9.3	0.4 (−7.4, 8.3)	0.91
Bone Strength (Femoral Neck)
CSMImax(mgxcm)	−1462±2810	1345±3044	−2807 (−5367, −247)	0.03
SMmax (cm3)	−2.4±4.07	2.22±3.60	−4.62 (−7.90, −1.35)	0.008
CSMImin (mgxcm)	−160±518.8	298±662	−458 (−989, 74)	0.09
SMmin (cm3)	−0.6±1.3	1.1±2.0	−1.7(−3.26, −0.09)	0.04
Bone Markers
CTX (ng/mL)	0.05±0.2	0.1±0.1	−0.02 (−0.2, 0.1)	0.77
BAP (U/L)	−0.2±2.5	−0.3±5.7	0.1 (−4.1, 4.3)	0.97
PTH (pg/mL)	−4.1±13.0	8.0±16.1	−12.0 (−25.1, 1.0)	0.07
Vitamin D (25OH) (ng/mL)	2.4±7.1	1.3±6.5	1.1 (−4.7, 7.0)	0.69

^*P values are based on a 2-group t test.

BMD: bone mineral density; CSMI_max: cross-sectional moment of inertia, strong axis of bone; CSMI_min: cross-sectional moment of inertia, weak axis of bone; Z_max: section modulus, strong axis of bone; Z_min: section modulus, weak axis of bone; CTX: C-terminal telopeptide of type I collagen; BAP: bone-specific alkaline phosphatase.