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The downstream target genes of the transcriptional factors p53, Rb, FoxM1, and Myc. The network displays the relationship between the four upstream regulators and their target molecules in PAH cells. The colors indicate the level of mRNA expression: upregulated genes are represented in red and downregulated genes in green. HPAH and IPAH displayed similar changes in RNA expression. The details of the genes in the diagram are described in Supplementary Table S6.
